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Actions	Malignant osteoclastoma of the ulna Remove from selection Add to selection Object numberGC.10566 TitleMalignant osteoclastoma of the ulna Creator W. Mercer DescriptionUlna. Malignant osteoclastoma of From a female aged 77 who two and a half years previously began to have pain in the right elbow and some swelling behind the joint. Four months later she was referred to hospital. She was frail but otherwise fit. There was a tender swelling in the region of the olecranon, and movements at the elbow were painful. Radiographs showed what was thought to be a benign giant-cell tumour of the olecranon. A biopsy was done and microsections showed numerous large multinucleated giant cells resembling osteoclasts lying amongst a background of pleomorphic cells which displayed frequent mitotic activity. The cellular matrix was considered to be frankly sarcomatous in character. The blood vessels were of a primitive sinusoidal type and several contained tumour cells in their lumina. Radiographs also revealed early Paget’s disease in the right radius and pelvis. In view of the patients age a trial of radiotherapy was made with same temporary improvement. The tumour, however, soon began to increase in size and became more tender. During the last month growth was very rapid. Pain became very distressing and the patient very willingly submitted to amputation of the limb. The medial half of the right elbow is shown. The olecranon and upper part of the ulna have been completely replaced by a tumour which extends above into the olecranon fossa, and is invading the triceps muscle. The coronoid process and part of the tendon of the brachialis muscle have also been replaced by tumour. In the ulna the tumour extends to 7 c.m. below the level of the elbow joint. The junction between tumour and invaded muscle and bone is well defined but there is no evidence of a fibrous barrier. Microsections of the tumour after amputation showed extensive areas similar to that seen in the biopsy two years previously, but there were also areas of crowded large polyhedral cells with darkly staining nuclei, varying in size, and often in mitosis. Other areas showed formation of osteoid tissue, the appearance being that of osteogenic sarcoma. Production date 1954 Production periodTwentieth century, mid Object nameJOINT, elbow Object categoryAnatomical, specimen, HISTOLOGY Dimensions Specimen Height: 23.2 cm Width: 17.8 cm Depth: 10.2 cm Slide Length: 7 cm Width: 2.5 cm

Object numberGC.10566

TitleMalignant osteoclastoma of the ulna

DescriptionUlna. Malignant osteoclastoma of From a female aged 77 who two and a half years previously began to have pain in the right elbow and some swelling behind the joint. Four months later she was referred to hospital. She was frail but otherwise fit. There was a tender swelling in the region of the olecranon, and movements at the elbow were painful. Radiographs showed what was thought to be a benign giant-cell tumour of the olecranon. A biopsy was done and microsections showed numerous large multinucleated giant cells resembling osteoclasts lying amongst a background of pleomorphic cells which displayed frequent mitotic activity. The cellular matrix was considered to be frankly sarcomatous in character. The blood vessels were of a primitive sinusoidal type and several contained tumour cells in their lumina. Radiographs also revealed early Paget’s disease in the right radius and pelvis. In view of the patients age a trial of radiotherapy was made with same temporary improvement. The tumour, however, soon began to increase in size and became more tender. During the last month growth was very rapid. Pain became very distressing and the patient very willingly submitted to amputation of the limb. The medial half of the right elbow is shown. The olecranon and upper part of the ulna have been completely replaced by a tumour which extends above into the olecranon fossa, and is invading the triceps muscle. The coronoid process and part of the tendon of the brachialis muscle have also been replaced by tumour. In the ulna the tumour extends to 7 c.m. below the level of the elbow joint. The junction between tumour and invaded muscle and bone is well defined but there is no evidence of a fibrous barrier. Microsections of the tumour after amputation showed extensive areas similar to that seen in the biopsy two years previously, but there were also areas of crowded large polyhedral cells with darkly staining nuclei, varying in size, and often in mitosis. Other areas showed formation of osteoid tissue, the appearance being that of osteogenic sarcoma.

Production date 1954

Production periodTwentieth century, mid

Object nameJOINT, elbow

Object categoryAnatomical, specimen, HISTOLOGY

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