Gall-bladder showing cholesterolosis
Object numberGC.10479
TitleGall-bladder showing cholesterolosis
DescriptionGall-bladder showing cholesterolosis. This is a change in the gall-bladder wall as the result of too much cholesterol.
From a married woman aged 63 years who had always been healthy but experienced discomfort in her upper abdomen for nine months. Cholecystography suggested a non-functioning gall-bladder. At operation the gall-bladder was of normal wise and adherent to the first part of duodenum and omentum. The under aspect of the gall-bladder, when separated from the duodenum, presented on its surface a white indurated plaque. The gall-bladder was removed.
On microsection the indurated plaque was seen to consist of granulation in collagenous fibrous tissue with considerable perivascular polymorphonuclear cell infiltration. The fibrosis did not extend deeply in the wall of the gall-bladder and was presumed therefore to be secondary to a peptic ulcer in the duodenum. The gall-bladder when opened, contained bile stained fluid but no stone and the mucosa showed marked cholesterosis.
In this specimen the gall-bladder, which is of normal size, has been laid open by a longitudinal incision on its dorsal surface. On the under aspect there is a white indurated area about 2 cm in diameter with a roughened central portion where it was adherent to the duodenum. Elsewhere there is a slight excess of subserous fat and extravasation of blood due to trauma at the operation. The mucosal surface shows numerous yellow distended villi, mostly situated on the ridges and thereby accentuating the normal reticulation. Towards the neck, the villi are arranged in longitudinal lines. A few minute yellow villi are present on the summit of the first mucosal fold at the neck but the cystic duct, as usual, is free.
Object nameGALLBLADDER
Object categoryAnatomical, specimen
Dimensions
- Height: 13 cm
Width: 7.5 cm
Depth: 4 cm